Last updated December 2025

Early-Phase Psychosis: Practice-Based Research to Improve Treatment Outcomes (ESPRITO2)

Principal Investigator:

Delbert Robinson, MD

Overview

Our hub is associated with 12 Coordinated Specialty Care (CSC) programs located in Florida, Michigan, Nevada, Oklahoma, Oregon, and South Carolina. All programs employ the NAVIGATE treatment model, serve diverse populations and except for one are community non-academic facilities.

See the full list of ESPRITO clinics

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Features

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Our group has a long-standing commitment to improving care for individuals with first episode psychosis (FEP), e.g. we developed the NAVIGATE CSC treatment model for the RAISE-ETP study. The current ESPRITO2 project allows us to improve FEP care within a learning health system (LHS) framework. The ESPRITO2 central team provides sites with core services, including support for data collection and using the resulting information to identify methods to improve care through dashboards and learning collaboratives.
Two research studies will address specific challenges in CSC services.
1. One project determines the clinical characteristics of individuals who disengage from the LHS or from NAVIGATE treatment. Using data that can be obtained during clinical care, we will characterize patient participants who disengage at two levels: those who enroll in the LHS but do not participate in the data collection needed for measurement-based care and those who prematurely terminate all CSC treatment.
2. Our second project determines the utility at real world clinics of automated speech and language analysis to identify participants at risk for treatment disengagement or for relapse and hospitalization. Automated speech and language analysis has the potential to provide sites important information about patient status beyond what is obtained by usual clinical measures.